{"id":2569,"date":"2024-01-29T10:58:04","date_gmt":"2024-01-29T10:58:04","guid":{"rendered":"http:\/\/cari-mumbai.res.in\/cari\/?page_id=2569"},"modified":"2026-02-26T07:07:50","modified_gmt":"2026-02-26T07:07:50","slug":"research","status":"publish","type":"page","link":"https:\/\/carikolkata.ccras.res.in\/?page_id=2569","title":{"rendered":"Clinical Research"},"content":{"rendered":"\t\t
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\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Clinical Research Projects<\/strong><\/h5>
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LIST OF ONGOING AND COMPLETED IMR AND COLLABORATIVE PROJECTS<\/strong><\/h5>
List of Ongoing Intra Mural Research Project:<\/strong><\/h5>
  1. Anti-hyperuricemic and anti-gouty arthritis activities of Amritadi guggulu on monosodium urate crystal induced in Wistar rats<\/h5><\/li>
  2. Evaluation of acute, sub-acute (28 days) and chronic (180 days) repeated dose oral toxicity study of AYUSH-56 in experimental animals<\/h5><\/li>
  3. Evaluation of acute dermal toxicity, 90 days repeated dose dermal toxicity, analgesic and anti-inflammatory activity of AYUSH MML Oil in Rodent Model<\/h5><\/li>
  4. Evaluation of acute and 90-days subchronic dermal toxicity of LK-Gel<\/em><\/h5><\/li><\/ol>
    Evaluation of selected Ayurvedic plants and formulations for their anti-diabetic activity using in-silico <\/em>screening and its in-vitro<\/em> validation<\/h5>
    List of Ongoing Intra Mural Research Collaborative Project:
    <\/strong>
    1.Anticancer potential and molecular mechanism of Rasa Sindhoor on Ovarian cancer cells (CSIR-IICB, Kolkata)
    2.Toxicity Profile of Rasamanikya Rasa in Experimental Animals (CSIR-IITR, Lucknow)
    3.Aqueous and hydroalcoholic extraction of selected Anukta Dravya plants and evaluation of their therapeutic efficacy for various diseases (Sambalpur University, Odisha)
    4.Evaluation of effect of AYUSH M3 and Prabhakar vati on cardiovascular parameters (CSIR-CDRI, Lucknow)
    5.Evaluation of Coded drug Ayush Rasayana B for treatment of high-altitude sickness using multi-dimensional drug discovery approach (IIT-BHU, Lucknow)
    6.Vidangadi Lauham, a novel Ayurvedic formulation in the management of diabetes and associated pathological complications. (SNPS, Jadavpur University, Kolkata)<\/h5>
    List of\u00a0 Completed Intra Mural Research Projects<\/strong><\/h5>

    \u00a0<\/p>

    1.Evaluation of hypoglycemic, hepatoprotective and anti-dyslipidemic activity of Parijaat (Nyctanthesarbor-tristis Linn.) flower extract in experimental animals).
    2.Evaluation of Anti-arthritic activity of Trayodashang guggulu in Complete Freund\u2019s Adjuvant induced arthritic rat model.
    3.Evaluation of in vivo antidiabetic activity of AYUSH-82
    4.Evaluation of Anti-inflammatory, Anti-arthritic and Analgesic activity of Simhanada guggulu on experimental animal models
    5.Toxicity Study & Evaluation of Anti-dyslipidemic Activity of Vyosadi guggulu in Wistar Rats.
    6.Evaluation of Kalyanaka Ghrita against rat model of Alzheimer\u2019s disease
    7.Evaluation of anti-diabetic and Hepatoprotective Activity of Coded Formulation AYUSH-64 in Experimental animal models<\/h5>
    \u00a0<\/h5>
    Completed Intra Mural Research Collaborative Projects<\/strong><\/h5>
    1. Mechanistic investigations on the efficacy and mode of action of Ashwagandha and Yogaraj Guggulu, using a hybrid Proteomics-Cheminformatics-Network medicine approach for the treatment of Osteoarthritis (IIT, Guwahati).<\/h5><\/li>
    2. Deciphering pharmacodynamics of Ayurvedic formulations (AYUSH Manas, Amrit Bhallataka Ghrita and Jyotishmati Taila) used in the Treatment of Neurodegenerative Diseases by Integrating Reverse Pharmacological Approaches (NIPER, Guwahati).<\/h5><\/li>
    3. Preclinical Evaluation and the Molecular Mechanism of Ayush 64 against Non-alcoholic fatty liver disease (NAFLD) and Non-alcoholic Steatohepatitis (NASH) in murine model (NIPER, Kolkata).<\/h5><\/li>
    4. Evaluation of the inhibition potential of Ayurvedic drugs against cytochrome P-450: implications for drug-drug interaction (NIPER, Kolkata).<\/h5><\/li><\/ol>
      Collaborating Institutes<\/strong>: CSIR-CDRI, Lucknow; Sambalpur University, Odisha; CSIR-IITR Lucknow; CSIR-IICB, Kolkata; IIT-BHU; IIT-Guwahati, NIPER-Guwahati, NIPER- Kolkata, and Jadavpur University, Kolkata.



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      \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 HOSPITAL DIVISION<\/strong><\/h5>
      \u00a0<\/strong><\/h5>
      General Information<\/strong><\/h5>
      • Fees for OPD registration, New registration fees 10\/- and Renewal Every monthRs. 10\/-<\/h5><\/li>
      • For Senior Citizens (documents to be verified\/ at the discretion of In-charge):<\/h5><\/li>
      • OPD Registration and other service charges (including pathology \/ Bio-chemistry investigations, bed charges, X-ray, panchakarma and other procedure) is 40% applicable for Senior Citizens<\/h5><\/li>
      • Research programme cases of the Council- exempted from all charges.<\/h5><\/li>
      • Patients belonging to below poverty line (BPL)<\/h5><\/li><\/ul>
        (Documents to be verified\/ at the discretion of In-charge) \u2013<\/h5>
        Exempted from all charges: Free<\/h5>
        OPD time Schedule<\/strong><\/h5>
        • OPD registration for general patients: 9 a.m. \u2013 12.30 p.m. Research Cases: as per\u00a0 time fixed by the concerned investigators : (10 a.m. \u2013 5 p.m.).<\/h5><\/li>
        • Reporting for adverse Drug Reactions \/ Events: 10 a.m. to 4 p.m.<\/h5><\/li><\/ul>
          OPD day Schedule<\/strong><\/h5>
          • General OPD: Daily (except 2nd<\/sup>Saturday, Sunday and Holidays)<\/h5><\/li>
          • Reporting Adverse Drug Reaction \/ Events: Daily (at PPC Room H\/G 01)\u00a0<\/strong><\/h5><\/li><\/ul>
            Facilities available at Hospital<\/strong><\/h5>
            • Free consultation for treatment and support service<\/h5><\/li>
            • 20 bed strength at IPD<\/h5><\/li>
            • In-house diet supply<\/h5><\/li>
            • All series of quality Ayurvedic medicines are available<\/h5><\/li>
            • Daily Panchakarma procedures<\/h5><\/li>
            • Biochemistry, Pathology and Radiology test<\/h5><\/li>
            • Tie up for CGHS empanelled laboratory for special tests<\/h5><\/li>
            • Round the clock doctors and paramedical staff<\/h5><\/li>
            • Digital X-ray everyday<\/h5><\/li>
            • 24 x 7 security personnel<\/h5><\/li><\/ul>
              \u00a0<\/strong><\/h5>
              Visiting time at IPD<\/strong><\/h5>
              Evening : 4 p.m. \u2013 6 p.m.<\/h5>
              \u00a0<\/strong><\/h5>
              Specialty Clinic<\/strong><\/h5>
              • Panchakarma Clinic<\/h5><\/li>
              • General Health Care Clinic<\/h5><\/li><\/ul>
                A total number of 1,44,488 patients have attended O.P.D. during the last six year (2019-2025). Out of them, 79,823 patients were males, 64,658 patients were females and 07 transgender patients, which include 2286 male children and 1994 female children. Total 1125 patients with different ailments were\u00a0 admitted in the IPD of the hospital section during the last five year as part of the clinical research. Out of which mostly cases were suffering from Amavata, Sandhivata, Vatavyadhi, Bhagandara and Arsha, Pakshaghata. Remaining were cases of Gridhrashi, Katishoola, Katigraha, Kitibha, Madhumeha etc. and were admitted on the basis of provisional diagnosis. The percentage of bed occupancy rate during the last six years (2019-2025) recorded was 74.35%, 29.55%, 30.46%, 59.58%, 57.62% and 42.77% respectively<\/h5>
                \u00a0<\/strong><\/h5>
                III. The following projects have been carried in last 10 years<\/strong>:<\/h5>
                1. Development of Quality standards and SOP for the Ayurvedic Formulation TriphalaKwathChurna<\/h5><\/li>
                2. Development of Quality standards and SOP for the Ayurvedic Formulation ApamargaTeekshanaKshara<\/h5><\/li>
                3. Development of Quality standards and SOP for the Ayurvedic Formulation DasmulaTaila<\/h5><\/li>
                4. Development of Quality standards and SOP for the Ayurvedic Formulation AYUSH SS Granules<\/h5><\/li>
                5. Development of Quality standards and SOP for the Ayurvedic Formulation AYUSH HR<\/h5><\/li>
                6. Development of Quality standards and SOP for the Ayurvedic Formulation BharangyadiKwathChurna<\/h5><\/li>
                7. Development of Quality standards and SOP for the Ayurvedic Formulation NimbadiKwathChurna<\/h5><\/li>
                8. Development of Quality standards and SOP for the Ayurvedic Formulation PanchavalkalKwathChurna<\/h5><\/li>
                9. Development of Quality standards and SOP for the Ayurvedic Formulation UdumbaradiTaila<\/h5><\/li>
                10. Quality Monographs of Indigenous medicinal plants Development of Pharmacopeial standards funded by PCIM&H<\/h5><\/li>
                11. Development of Quality standards and SOP for the Ayurvedic Formulation AYUSH-KVM<\/h5><\/li>
                12. Development of Quality standards and SOP for the Ayurvedic Formulation SarpagandhaMishran<\/h5><\/li>
                13. Development of Quality standards and SOP for the Ayurvedic Formulation LekhaniyaGanaKashaya<\/h5><\/li>
                14. Development of Quality standards and SOP for the Ayurvedic Formulation KubearkshVati<\/h5><\/li>
                15. Development of Quality standards and SOP for the AyushBalaRakshakLeham<\/h5><\/li>
                16. Development of Quality standards and SOP for the AyushBalaRasayana Tablet<\/h5><\/li>
                17. Isolation of Phytoconstituents from some selected Ayurvedic medicinal plants<\/h5><\/li>
                18. Isolation of marker\/PRS compounds of selected medicinal plants<\/h5><\/li>
                19. Development of Quality standards and Monographs of 10 indigenous medicinal plants<\/h5><\/li>
                20. Elucidation of Critical Control points in manufacturing of selected classical Ayurvedic formulation for quality assurance<\/h5><\/li>
                21. Rationalization of hydro-alcoholic extractive protocols for selected plant roots\/rhizomes of Ayurvedic importance for strategic drug development<\/h5><\/li>
                22. Phyto-chemical analysis of LakshaGuggulu and the coded drug Ayush-osto with mechanistic preclinical evaluation in amelioration of osteoporosis & healing of bone fracture employing in silico, in vitro and in vivo\u00a0studies<\/h5><\/li>
                23. Documentation of Life Profiles of Luminaries in Ayurveda<\/h5><\/li>
                24. Development of Quality Standards, SOP and Shelf-life Study for Ayurvedic formulation PanchanimbaChurna<\/h5><\/li>
                25. Development of Quality Standards, SOP and Shelf-life study for Ayurvedic formulations viz. AbhadyaChurna&amp; UtpaladyaChurna<\/h5><\/li>
                26. Multi-component based analytical discrimination and species specific herboprint development of various therapeutically important Berberis species<\/h5><\/li>
                27. Evaluation of clinical efficacy and safety of the Vamana karma followed by oral administration of YasadBhasma along with Triphalachuma in kitibha (Psoriasis)<\/h5><\/li>
                28. Clinical evaluation of KusmandaRasayana in the management of Chronic Bronchitis (KaphajaKasa)<\/h5><\/li>
                29. An Open Label Study to Assess the Clinical Efficacy & Safety of C1 Oil for Eczema and Woundhealing-a pilot study.<\/h5><\/li>
                30. Clinical Efficacy and Safety of BrihatGangadharChurna in the management of Irritable Bowel Syndrome.<\/h5><\/li>
                31. Clinical evaluation of certain Ayurvedic formulation in the management of Sthoulya (Obesity)<\/h5><\/li>
                32. Clinical Evaluation of TriphalaGuggulu and Kashishaditaila in the management of Arsha (Haemorrhoids)<\/h5><\/li>
                33. Clinical Evaluation of Ayurvedic formulation in the Management of Parikartika (Fissure-in-Ano)<\/h5><\/li>
                34. Collaborative multi-centric clinical trial to study the effect of AYUSH Rasayana (A & B) on ageing in apparently healthy elderly subjects<\/h5><\/li>
                35. Clinical evaluation of LaksaGuggulu, MuktashuktiBhasma, in the management of Osteoporosis \/ Osteopenia<\/h5><\/li>
                36. Development and Validation of Prakriti Assessment Questionnaire \/ Scale<\/h5><\/li>
                37. Central Sector Scheme for Pharmacovigilance of Ayurveda, Siddha, Unani and Homoeopathy Drugs under Ministry of AYUSH, Government of India<\/h5><\/li>
                38. Clinical Evaluation of Eladichurna and Draksharishta in the management of Kasa (Stable chronic Bronchitis)<\/h5><\/li>
                39. Clinical Evaluation of Efficacy of IndukantaGhrita and TrayodasangaGuggulu in the management of Rhematoid Arthritis vis-\u00e0-vis Amavata<\/h5><\/li>
                40. Clinical Evaluation of AvipattikarChurna in the management of Amlapitta (Functional Dyspepsia)<\/h5><\/li>
                41. Multicentric collaborative placebo controlled study on clinical evaluation of AYUSH-SL in chronic filarial lymphoedema in patients receiving mass drug administration.<\/h5><\/li>
                42. Observation on fistula cutting time with Ksharasutra used in routine patients of Anorectal fistula (Bhagandara)<\/h5><\/li>
                43. AYUSH Hospital Management Information System<\/h5><\/li>
                44. A prospective non-randomized open label controlled interventional study on the effect of GuduchiGhanVati \/ SudarshanGhanVati as a prophylactic measure among containment zone population exposed to COVID-19<\/h5><\/li>
                45. A prospective open label controlled interventional study on the effect of Ayurvedic intervention (Ayurveda Raksha Kit) as a prophylactic measure in the Pandemic of COVID-19 A community-based study<\/h5><\/li>
                46. A prospective open labelled observational study to document the potential safety issues and prescription trends in selected Rasausadhi\u2019s in CCRAS-OPD\u2019s across India<\/h5><\/li>
                47. Integration of AYUSH System of Medicine within the National Health System to Combat COVID -19\u201d<\/h5><\/li>
                48. Clinical Evaluation of GokshuradiGuggulu and NimbadiChurna in Vatarakta (Gout)<\/h5><\/li>
                49. Morbidity and Healthcare-seeking behaviour of the patients visiting the Ayurveda healthcare facilities of the\u00a0DGAFMS\u00a0Hospitals: A cross-sectional survey study<\/h5><\/li>
                50. General health screening with special focus on selected disease conditions (Tuberculosis, Anemia, Sickle Cell Disease & Malnutrition)and Ayurveda management of Anemia and Malnutrition in students of Ekalavya Model Residential Schools (EMRS)<\/h5><\/li>
                51. Randomized Open Label Comparative Clinical Study on Management of\u00a0Depression\u00a0by Ayurveda and Yoga as Auxiliary Therapies in Combination with Conventional Treatment<\/h5><\/li>
                52. Central Sector Scheme namely AOGUSY-AyushOushadhiGuvnattaevunUttapadanSamvardhanYojana (Pharmaco-Vigilance)<\/h5><\/li>
                53. Development of SOP s and quality standards for the formulation AYUSH 56.<\/h5><\/li>
                54. Process Validation and Pharmaceutical Standardization and Estimation of Shelf life<\/h5><\/li>
                55. Study of VacalasunadiTaila, SomarajiTaila, HingutrigunaTaila and YastimadhuGhrita.<\/h5><\/li>
                56. Development of SOP and quality standards of Ayurvedic herbomineral formulation GandhakRasayan.<\/h5><\/li>
                57. Systemic survey of the labeling information of of the Ayurvedic Drugs included in NLEAM and marketed in India in compliance with rule 161 of the D & C act 1940 and rule 1945<\/h5><\/li>
                58. Process Validation & Pharmaceutical Standardization and Estimation of Shelf Life Study of AbhijitaTaila, MadhukadiTaila, <\/em>&VyaghriTaila<\/em><\/h5><\/li>
                59. Effectiveness of Drakshavaleha in Improving the Symptoms of Functional Gastrointestinal Disorders. \u2013 A Multi-Centre Study<\/h5><\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

                  \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Clinical Research Projects \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0<\/p>\n","protected":false},"author":1,"featured_media":2602,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2569","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/carikolkata.ccras.res.in\/index.php?rest_route=\/wp\/v2\/pages\/2569","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/carikolkata.ccras.res.in\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/carikolkata.ccras.res.in\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/carikolkata.ccras.res.in\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/carikolkata.ccras.res.in\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2569"}],"version-history":[{"count":50,"href":"https:\/\/carikolkata.ccras.res.in\/index.php?rest_route=\/wp\/v2\/pages\/2569\/revisions"}],"predecessor-version":[{"id":3886,"href":"https:\/\/carikolkata.ccras.res.in\/index.php?rest_route=\/wp\/v2\/pages\/2569\/revisions\/3886"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/carikolkata.ccras.res.in\/index.php?rest_route=\/wp\/v2\/media\/2602"}],"wp:attachment":[{"href":"https:\/\/carikolkata.ccras.res.in\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2569"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}